Illustrative Instrument-Borrowing Example

A simulated summary-statistics example for the IBMR workflow with one exposure, one primary outcome, and two candidate auxiliary outcomes. The data are simulated (not real GWAS data): the exposure has a genuine positive effect on the primary outcome, Auxiliary_1 shares pleiotropic (invalid-instrument) structure with the primary outcome and is therefore informative for instrument borrowing, while Auxiliary_2 shares little and is not.

Usage

data(ibmr_example)

Format

A named list with the following entries:

BetaXG

Numeric vector of SNP-exposure associations.

seBetaXG

Standard errors for BetaXG.

BetaYG_matrix

Matrix of SNP-outcome associations; columns Primary, Auxiliary_1, and Auxiliary_2.

seBetaYG_matrix

Standard errors matching BetaYG_matrix.

primary_trait

"Primary".

candidate_auxiliaries

c("Auxiliary_1", "Auxiliary_2").

recommended_auxiliary

"Auxiliary_1".

dat_ibpresso_aux1

Data frame formatted for IBPRESSO() with the primary outcome and the recommended auxiliary outcome (Auxiliary_1).

source_note

Description of how the example was generated.